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Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds
Published on: February 11, 2021
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The Terminal End Bud: the Little Engine that Could
Ingrid S Paine1, Michael T Lewis2,3
1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Journal of Mammary Gland Biology and Neoplasia
|February 8, 2017
Summary
The mammary gland
Area of Science:
- Mammary gland development
- Cellular biology
- Developmental biology
Background:
- The mammary gland exhibits significant regeneration, with most development occurring postnatally.
- The terminal end bud (TEB) orchestrates ductal tree formation and mammary gland elongation.
- TEB controls basement membrane deposition, branching, angiogenesis, and pattern formation.
Purpose of the Study:
- To summarize current understanding of terminal end bud (TEB) biology.
- To highlight recent findings on pubertal mammary gland outgrowth and ductal elongation.
- To discuss TEB as a model for breast cancer research.
Main Methods:
- Literature review of mammary gland development studies.
- Analysis of pubertal outgrowth and ductal elongation processes.
- Exploration of TEB's role in tissue patterning and regeneration.
Main Results:
- TEB is crucial for ductal elongation and mammary gland development.
- Local regulatory factors in TEB are less understood than hormonal control.
- Recent studies reveal novel insights into TEB processes during pubertal growth.
Conclusions:
- TEB biology is key to understanding mammary gland regeneration and development.
- Further research is needed to elucidate local regulatory factors within the TEB.
- The TEB serves as a valuable model for investigating breast cancer origins and progression.
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