Related Experiment Video
Updated: Mar 7, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Synthesis and evaluation of an injectable everolimus prodrug
Haibo Wang1, Xiaohe Zheng1, Zhengjiang Cai1
1Zhejiang Hisun Pharmaceutical Co., Ltd., 46 Waisha Rd., Taizhou, Zhejiang 318000, PR China.
Abstract:
A novel water-soluble everolimus prodrug, glutathione-everolimus, was designed and synthesized by introducing an endogenous tripeptide with an acetyl as the linker. The improvement in water solubility allowed the conjugate to be developed into an injectable drug. The results of biological evaluation in vitro and in vivo suggested that the prodrug was more effective and long acting than everolimus. Meanwhile, the pharmacokinetics study in vivo confirmed that the delivery of everolimus through the injection of the prodrug can overcome the low bioavailability of oral everolimus.
More Related Videos
Related Concept Videos
Prodrugs
Prodrugs help overcome...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Rate-Programmed I
Modified-Release Drug Delivery Systems: Bioavailability
Modified-Release Drug Delivery Systems: Site-Targeted

