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Reward loss and addiction: Opportunities for cross-pollination
Leonardo A Ortega1, José L Solano1, Carmen Torres2
1Department of Psychology, Fundación Universitaria Konrad Lorenz, Bogotá, Colombia.
Pharmacology, Biochemistry, and Behavior
|February 9, 2017
Summary
Exploring reward loss in substance use disorders reveals shared neurochemical systems and brain circuitry. This integration enhances understanding of addiction and opens new research avenues for treatment.
Area of Science:
- Neuroscience
- Psychobiology
- Addiction Research
Background:
- Paradigms for studying reward loss are underutilized in substance use disorder research.
- Integrating reward loss and addiction psychobiology offers novel insights.
Purpose of the Study:
- To review parallels between reward loss response and addiction psychobiology.
- To explore emerging research avenues benefiting from this integrated perspective.
Main Methods:
- Review of neurochemical systems (opioid, GABA, dopamine) in both reward loss and addiction.
- Analysis of overlapping brain circuitry (amygdala, striatum, prefrontal cortex).
Main Results:
- Shared neurochemical systems modulate behavioral effects of reward loss and addiction.
- Significant overlap exists in brain circuitry underlying reward loss and addiction.
Conclusions:
- Understanding reward loss is crucial for a deeper comprehension of addiction initiation and maintenance.
- Cross-disciplinary approaches can advance both reward loss research and addiction treatment strategies.
Keywords:
AddictionNegative emotionReward comparisonReward devaluationReward lossReward omissionSubstance use disorderMore Related Videos
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