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Updated: Mar 7, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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The Farnesoid X Receptor: Good for BAD

Stephen J Keely1, Julian R F Walters2

  • 1Molecular Medicine Laboratories, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

Cellular and Molecular Gastroenterology and Hepatology
|February 9, 2017
PubMed
Summary

Bile acid diarrhea affects 1% of adults, with current treatments often failing. Farnesoid X receptor (FXR) agonists show promise for treating this condition by regulating bile acid synthesis and fluid secretion.

Keywords:
ASBT, apical sodium-linked bile acid transporterBAD, bile acid diarrheaBile Acid DiarrheaC4, 7α-hydroxy-4-cholesten-3-oneCA, cholic acidCDCA, chenodeoxycholic acidChloride SecretionDCA, deoxycholic acidEHC, enterohepatic circulationEnterohepatic CirculationEpitheliumFGF-19FGF19, fibroblast growth factor 19FXR, farnesoid X receptorLCA, lithocholic acidOCA, obeticholic acid

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