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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Transforming Cancer Epigenetics Using Nutritive Approaches and Noncoding RNAs

Centdrika R Dates1, Trygve O Tollefsbol1,2,3,4,5

  • 1Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.

Current Cancer Drug Targets
|February 9, 2017
PubMed

Insights

Nutrition and non-coding RNAs (ncRNAs) are key areas for cancer prevention and therapy. This review explores how ncRNAs, like long non-coding RNAs and microRNAs, are dysregulated in cancer, impacting gene expression and offering novel therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer remains a leading cause of death, necessitating novel therapeutic and preventive strategies.
  • Epigenetic alterations, including non-coding RNA dysregulation, are increasingly recognized as crucial in cancer development.
  • Nutrition plays a significant role in cellular homeostasis and cancer etiology.

Purpose of the Study:

  • To review the role of nutrition in cancer development and progression.
  • To examine the dysregulation of non-coding RNAs (ncRNAs) in various cancer types.
  • To highlight ncRNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), as potential biomarkers and therapeutic targets.

Main Methods:

  • Literature review focusing on cancer, nutrition, and non-coding RNA research.
  • Analysis of studies investigating gene expression and regulation in cancer.
  • Emphasis on high-throughput sequencing data for identifying dysregulated ncRNAs.

Main Results:

  • Non-coding RNAs, including lncRNAs and miRNAs, are frequently dysregulated in cancer, affecting gene expression.
  • Altered expression of specific ncRNAs correlates with cancer development and progression.
  • Nutritional factors can influence epigenetic mechanisms and ncRNA expression.

Conclusions:

  • Nutrition and ncRNA dysregulation are critical factors in cancer.
  • ncRNAs represent promising biomarkers for early detection and novel therapeutic targets in oncology.
  • Further research into the interplay between nutrition and ncRNAs can lead to innovative cancer prevention and treatment strategies.
Keywords:
Cancerepigeneticsnon-coding RNAnutritionpreventiontargetstherapy.

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