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Related Concept Videos

Genetic Lingo01:11

Genetic Lingo

Overview
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Genome Copying Errors02:46

Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genetic Material01:20

Genetic Material

Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.

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Related Experiment Video

Updated: Jul 3, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

Published on: April 19, 2013

Your genes are conspiring against you.

Olga Peñagarikano1

  • 1Department of Pharmacology, School of Medicine, University of the Basque Country, Leioa 48940, Spain.

Science Translational Medicine
|February 10, 2017
PubMed
Summary

Genetic variations in the dopamine receptor D2 network influence schizophrenia symptoms and treatment outcomes. Understanding these gene variants offers insights into personalized medicine for schizophrenia patients.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Schizophrenia is a complex psychiatric disorder.
  • Dopamine receptor D2 (DRD2) plays a crucial role in schizophrenia pathophysiology.
  • Genetic factors significantly contribute to schizophrenia susceptibility and heterogeneity.

Purpose of the Study:

  • To investigate the association between gene variants in the DRD2 expression network and schizophrenia.
  • To determine if these variants predict clinical and physiological features of schizophrenia.
  • To assess the impact of these variants on treatment response in schizophrenia patients.

Main Methods:

  • Utilized genetic association studies.
  • Analyzed gene expression data related to the DRD2 network.

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Last Updated: Jul 3, 2026

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  • Correlated genetic findings with clinical assessments and physiological measures.
  • Evaluated treatment response based on genetic profiles.

    • Main Results:

    • Identified specific gene variants within the DRD2 network associated with schizophrenia.
    • Demonstrated a predictive relationship between these variants and distinct physiological and clinical phenotypes.
    • Showed that DRD2 network gene variants correlate with differential responses to antipsychotic treatments.

    Conclusions:

    • Gene variants in the DRD2 expression network are significant predictors of schizophrenia characteristics.
    • These findings highlight the potential of DRD2 network genetics for personalized treatment strategies in schizophrenia.
    • Further research into the DRD2 network may uncover novel therapeutic targets for schizophrenia.