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Updated: Mar 7, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
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Published on: November 11, 2008

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Two Cycles with One Catch: Hydrazine in Ugi 4-CR and Its Postcyclizations

Yuanze Wang1, Pravin Patil1, Katarzyna Kurpiewska2

  • 1University of Groningen , Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

ACS Combinatorial Science
|February 10, 2017
PubMed
Summary

This study explores isocyanide-based multicomponent reactions (IMCR) using N-Boc protected hydrazine and α-amino acid isocyanides. Post-cyclization modifications under acidic and basic conditions yield diverse tetrazolopyrazinone and tetrazolotriazepinone derivatives.

Keywords:
European Lead Factoryhydrazineisocyanide-based multicomponent reactionsone-pot synthesispost cyclizationscaffolds diversitytetrazole

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