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Fatigue in psoriasis: a controlled study.

I M Skoie¹, I Dalen², T Ternowitz¹

¹Department of Dermatology, Stavanger University Hospital, Stavanger, Norway.

The British Journal of Dermatology

|February 10, 2017

Summary

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Nearly half of psoriasis patients experience significant fatigue, impacting their quality of life. This fatigue is linked to smoking, pain, and depression, not disease severity.

Area of Science:

Dermatology
Psychology
Clinical Research

Background:

Fatigue is a common symptom in chronic inflammatory diseases.
Psoriasis, a chronic inflammatory skin condition, is increasingly recognized as having systemic effects.
Limited research has specifically investigated the prevalence and characteristics of fatigue in psoriasis patients.

Purpose of the Study:

To determine the prevalence and severity of fatigue in patients with chronic plaque psoriasis compared to healthy individuals.
To identify clinical and demographic factors associated with fatigue in psoriasis.
To assess the impact of fatigue on the quality of life for psoriasis patients.

Main Methods:

A comparative study involving 84 patients with chronic plaque psoriasis and 84 age- and sex-matched healthy controls.

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Fatigue assessment using the fatigue Visual Analogue Scale (fVAS), Fatigue Severity Scale (FSS), and Short Form 36 (SF-36) Vitality scale.

Disease activity measured by Psoriasis Area and Severity Index (PASI); quality of life by Dermatology Life Quality Index (DLQI).

Main Results:

Over 50% of psoriasis patients reported clinically significant fatigue across all three assessment tools, compared to only 2-4% in healthy controls (P < 0.001).
Median fVAS, FSS, and SF-36 Vitality scores were significantly worse in psoriasis patients than in controls.
Fatigue severity showed a correlation with Dermatology Life Quality Index scores in univariate analysis, but not with Psoriasis Area and Severity Index scores.

Conclusions:

Substantial fatigue affects nearly half of patients with psoriasis.
Fatigue in psoriasis is associated with factors such as smoking, pain, and depression.
Psoriasis disease severity (PASI) was not found to be a significant predictor of fatigue in this study.