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Sympathetic sudomotor function in diabetic neuropathy.

W R Kennedy1, X Navarro

  • 1Department of Neurology, University of Minnesota, Minneapolis.

Archives of Neurology
|November 1, 1989
PubMed
Summary

Diabetic neuropathy can affect sympathetic nerve function, impacting sweat glands. The Silastic mold technique, especially with computerized analysis, effectively detects these nerve issues, even in asymptomatic type I diabetic patients.

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Area of Science:

  • Neurology
  • Endocrinology
  • Dermatology

Background:

  • Type I diabetes can lead to sympathetic nerve dysfunction.
  • Assessing small fiber neuropathy in diabetic patients is crucial for early intervention.

Purpose of the Study:

  • To evaluate sympathetic nerve function in type I diabetic patients using the Silastic mold technique and evaporimetry.
  • To determine the sensitivity of the Silastic mold technique in detecting sympathetic nerve involvement.

Main Methods:

  • Studied 357 type I diabetic patients using Silastic mold technique and evaporimetry on hands and feet.
  • Utilized computerized analysis for automatic sweat gland counts and secretion volume estimation.

Main Results:

  • Abnormalities in sweat gland function were detected in a significant percentage of patients (24% hand, 56% foot).
  • Computerized Silastic mold analysis revealed abnormalities in 36% (hand) and 60% (foot) of patients.
  • The Silastic technique identified sympathetic nerve involvement even in asymptomatic individuals.

Conclusions:

  • The Silastic mold technique is a sensitive tool for detecting sympathetic nerve dysfunction in type I diabetes.
  • Computerized analysis enhances the sensitivity and accuracy of the Silastic imprint technique.
  • Early detection of nerve involvement is possible even with normal clinical examinations.

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