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Updated: Mar 7, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Drug- and Gene-eluting Stents for Preventing Coronary Restenosis
Kamali Manickavasagam Lekshmi1, Hui-Lian Che2, Chong-Su Cho3
1Department of Biomedical Sciences and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju, Korea.
Insights
Gene-eluting stents offer a promising alternative to traditional treatments for coronary artery disease (CAD). These advanced stents deliver genetic material to inhibit restenosis, improving outcomes for cardiovascular patients.
Area of Science:
- Cardiovascular Medicine
- Biomaterials Science
- Gene Therapy
Background:
- Coronary artery disease (CAD) is a leading global cause of mortality.
- Current treatments like angioplasty and bypass surgery have limitations, including in-stent restenosis (ISR).
- Stent technology requires improvement to overcome drawbacks like ISR.
Purpose of the Study:
- To review the molecular mechanisms of restenosis.
- To explore the application of drug- and gene-eluting stents for CAD treatment.
- To discuss the potential of multifunctional electronic stents as biosensors and targeted delivery systems.
Main Methods:
- Review of existing literature on coronary artery disease treatments.
- Analysis of molecular mechanisms underlying restenosis.
- Evaluation of gene-eluting stent technology and its components (DNA, siRNA, miRNA).
Main Results:
- Gene-eluting stents can inhibit neointimal formation by delivering specific genes.
- Multifunctional electronic stents offer potential for biosensing and condition-based drug/gene delivery.
- Gene-eluting stents represent an advancement over traditional drug-eluting stents.
Conclusions:
- Gene-eluting stents show significant promise for preventing and treating coronary restenosis.
- Multifunctional electronic stents could revolutionize ISR treatment through personalized, condition-specific interventions.
- Further research into gene-eluting and electronic stent properties is crucial for clinical success.
Abstract:
Coronary artery disease (CAD) has been reported to be a major cause of death worldwide. Current treatment methods include atherectomy, coronary angioplasty (as a percutaneous coronary intervention), and coronary artery bypass. Among them, the insertion of stents into the coronary artery is one of the commonly used methods for CAD, although the formation of in-stent restenosis (ISR) is a major drawback, demanding improvement in stent technology. Stents can be improved using the delivery of DNA, siRNA, and miRNA rather than anti-inflammatory/anti-thrombotic drugs. In particular, genes that could interfere with the development of plaque around infected regions are conjugated on the stent surface to inhibit neointimal formation. Despite their potential benefits, it is necessary to explore the various properties of gene-eluting stents. Furthermore, multifunctional electronic stents that can be used as a biosensor and deliver drug- or gene-based on physiological condition will be a very promising way to the successful treatment of ISR. In this review, we have discussed the molecular mechanism of restenosis, the use of drug- and gene-eluting stents, and the possible roles that these stents have in the prevention and treatment of coronary restenosis. Further, we have explained how multifunctional electronic stents could be used as a biosensor and deliver drugs based on physiological conditions.
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