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Published on: October 8, 2021
Programmable DNA triple-helix molecular switch in biosensing applications: from in homogenous solutions to in living
Pinting Tang1, Jing Zheng1, Jianru Tang1
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. zhengjing2013@hnu.edu.cn Yangrh@pku.ed.cn.
Abstract:
Herein, we demonstrated a new gold nanoparticles (AuNPs)-integrated programmable triple-helix molecular switch (THMS) to realize the biosensing of multiple targets from in homogenous solution to in living cells. The results demonstrated that this proposed programmable THMS could be successfully used for imaging multiple messenger RNA (mRNA) in living cells and it significantly extends the scope of the THMS sensing platform.
