A Difunctional Regeneration Scaffold for Knee Repair based on Aptamer-Directed Cell Recruitment
Xiaoxia Hu1, Yulan Wang2,3, Yaning Tan1
1Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Advanced Materials (Deerfield Beach, Fla.)
|February 11, 2017
Abstract:
To solve the challenge of poor knee repair, an aptamer-bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The scaffold can efficiently recruit MSCs to the defect and induce the directional differentiation of MSCs, thus successfully achieving simultaneous regeneration of cartilage and bone in the knee joint.
