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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

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Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
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Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
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Mitral Stenosis IV: Nursing Management01:27

Mitral Stenosis IV: Nursing Management

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A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...
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Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

498
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
498
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

450
Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
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Updated: Mar 7, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
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Thrombotic valvular dysfunction with transcatheter mitral interventions for postsurgical failures.

Marvin H Eng1, Adam Greenbaum1, Dee Dee Wang1

  • 1Department of Medicine, Henry Ford Health System, Center for Structural Heart Disease, Detroit, Michigan.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|February 11, 2017
PubMed
Summary
This summary is machine-generated.

Transcatheter mitral valve replacement (TMVR) shows promise for degenerated valves, with high initial success. However, 15% of patients experienced thrombosis, suggesting a need for anticoagulation over dual-antiplatelet therapy.

Keywords:
mitraltransapicaltranscatheter heart valvevalve thrombosisvalve-in-valve

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Biomaterials Science

Background:

  • Degenerated surgical mitral valve repairs and prostheses necessitate advanced treatment options.
  • Transcatheter mitral valve replacement (TMVR) is an emerging therapeutic strategy for these complex cases.
  • This study evaluates the procedural and mid-term outcomes of TMVR in a cohort of patients.

Purpose of the Study:

  • To assess the safety and efficacy of transcatheter mitral valve replacement (TMVR) in patients with degenerated surgical mitral valve repairs or prostheses.
  • To evaluate mid-term clinical outcomes and identify potential complications associated with TMVR.
  • To investigate the incidence and characteristics of valve dysfunction post-TMVR.

Main Methods:

  • A cohort of 13 consecutive patients with degenerated mitral valves underwent TMVR between December 2013 and December 2015.
  • Patients were monitored for procedural success and clinical outcomes defined by the Mitral Valve Academic Valve Consortium (MVARC).
  • Mid-term follow-up included assessment of valve gradients, leaflet motion, and adverse events such as thrombosis and stroke.

Main Results:

  • Immediate procedural technical success was achieved in 92% of cases.
  • At 30 days, MVARC device and procedure success rates were 61% and 84%, respectively.
  • Mid-term follow-up revealed a significant decrease in mean mitral gradient, but 15% of patients experienced thrombotic dysfunction, with abnormal leaflet thickening noted in one additional case.

Conclusions:

  • Transcatheter mitral valve replacement (TMVR) demonstrates favorable procedural success and hemodynamic improvement.
  • Thrombotic dysfunction occurred in 15% of patients, highlighting a potential complication of TMVR.
  • The findings suggest that oral anticoagulation may be necessary for patients undergoing TMVR, rather than dual-antiplatelet therapy, to mitigate thrombotic risks.