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Dioleoyl-phosphatidic acid selectively binds to α-synuclein and strongly induces its aggregation

Satoru Mizuno1, Hirotaka Sasai1, Aiko Kume1

  • 1Department of Chemistry, Graduate School of Science, Chiba University, Japan.

FEBS Letters
|February 11, 2017
PubMed
Summary

The fatty acyl chains of phosphatidic acid (PA) influence alpha-synuclein (α-syn) binding. Specifically, 18:1/18:1-PA shows the strongest binding and most effectively promotes α-syn aggregation, a key process in Parkinson's disease.

Keywords:
Parkinson's diseaseaggregationphosphatidic acidα-helixα-synuclein

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