Related Experiment Video
Updated: Aug 13, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Structure-activity relationships of peptide T-related pentapeptides
M Marastoni1, S Salvadori, G Balboni
1Department of Pharmaceutical Sciences, University of Ferrara, Italy.
Abstract:
Fifteen pentapeptide analogs of C-terminal fragment of peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, were prepared and tested for human monocyte chemotaxis. Structure-activity studies suggest that the potent chemotactic activity of H-Thr-Thr-Asn-Tyr-Thr-OH is mediated through the polar properties of the C-terminal carboxyl group and Thr side chains at the critical positions 5 and 8, while the hydroxyl group of N-terminal Thr and its free amino function are not essential requirements for CD4 receptor interactions.
Related Concept Videos
Protein Organization
Peptide Bonds
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme can...
tRNA Activation
Protein Organization
The primary structure of a protein is its amino acid sequence.
tRNA Activation

