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Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Mar 7, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing

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Implementing Genome-Driven Oncology.

David M Hyman1, Barry S Taylor2, José Baselga3

  • 1Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

Cell
|February 11, 2017
PubMed
Summary
This summary is machine-generated.

Genome-driven oncology promises personalized cancer care by targeting specific genetic mutations. However, challenges like tumor heterogeneity and complex trial designs require advanced strategies for effective implementation and biological discovery.

Keywords:
Precision medicinebasket studiesgenome-driven oncologynext-generation sequencingtargeted therapy

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Area of Science:

  • Genomic medicine
  • Oncology
  • Molecular biology

Background:

  • Early successes in identifying and targeting individual oncogenic drivers have paved the way for genome-driven oncology.
  • Advances in tumor genome sequencing are increasing the feasibility of personalized cancer care.

Purpose of the Study:

  • To review contemporary approaches addressing the complexities of implementing genome-driven oncology.
  • To highlight how these approaches can drive biological discovery and improve cancer treatment insights.

Main Methods:

  • Review of current strategies in genome-driven oncology.
  • Analysis of challenges in target credentialing, drug combinations, clinical trial design, and technological deployment.
  • Exploration of methods to address tumor heterogeneity.

Main Results:

  • Genome-driven oncology faces significant biological and clinical implementation challenges.
  • Key challenges include target validation, drug combinations, trial design, and addressing tumor heterogeneity.
  • Technological advancements beyond DNA sequencing are crucial.

Conclusions:

  • Contemporary approaches are being developed to overcome the complexities of genome-driven oncology.
  • These advancements are expected to enhance biological discovery and deepen our understanding of cancer and its treatment.
  • The field is evolving towards more sophisticated and integrated cancer care strategies.