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Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.

Nicholas McGranahan1, Charles Swanton2

  • 1Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Rd, London NW1 1AT, UK.

Cell
|February 11, 2017
PubMed
Summary

Intratumor heterogeneity drives cancer evolution and drug resistance. Novel therapeutic strategies targeting tumor evolution and the microenvironment are crucial for improving patient outcomes.

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