Related Experiment Video

Updated: Mar 7, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
09:40

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

6.0K

Long non-coding RNA in glioma: signaling pathways

Jia Shi1, Bo Dong1, Jiachao Cao1

  • 1Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Oncotarget
|February 11, 2017
PubMed

Insights

Long non-coding RNAs (lncRNAs) are crucial in glioma development. Understanding lncRNA mechanisms and their interactions with pathways like BRD4-HOTAIR and microRNAs (miRNAs) is key for new glioma therapies.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioma is the most common malignant brain tumor, necessitating novel therapeutic strategies.
  • Long non-coding RNAs (lncRNAs) play a significant role in glioma initiation and progression.
  • lncRNA dysregulation is linked to critical signaling pathways implicated in glioma.

Purpose of the Study:

  • To investigate the role of lncRNAs in glioma pathogenesis.
  • To explore the molecular mechanisms underlying lncRNA dysregulation in glioma.
  • To identify potential therapeutic targets for glioma treatment based on lncRNA function.

Main Methods:

  • Analysis of signaling pathways involved in lncRNA dysregulation (e.g., BRD4-HOTAIR-β-catenin/PDCD4, p53-Hif-H19/IGF2, CRNDE/mTOR).
  • Investigation of interactions between lncRNAs and microRNAs (miRNAs) in glioma, such as miR-675.
  • Review of current literature on lncRNA functions in central nervous system malignancies.

Main Results:

  • lncRNAs are dysregulated in glioma, contributing to tumor development.
  • Specific signaling pathways (BRD4-HOTAIR, p53-Hif, CRNDE/mTOR) are activated by lncRNA dysregulation.
  • lncRNAs interact with miRNAs, further influencing glioma progression.

Conclusions:

  • lncRNAs are critical regulators in glioma.
  • Understanding lncRNA-mediated signaling pathways and miRNA interactions is vital for developing effective glioma therapies.
  • Targeting lncRNA mechanisms offers a promising avenue for future glioma treatment strategies.
Keywords:
gliomalong non-coding RNAsmicroRNA

More Related Videos

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

16.6K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.5K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
6.0K