[Clinical symptoms in IgA deficiency].

Area of Science:

• Immunology
• Clinical Medicine
• Allergy and Immunology

Background:

• Selective IgA deficiency is the most prevalent primary immunodeficiency.
• Early diagnosis and management are crucial for improving patient quality of life.
• Further research into the clinical manifestations of IgA deficiency is warranted.

Purpose of the Study:

• To investigate and determine the clinical manifestations associated with IgA deficiency.

Main Methods:

• A cross-sectional, retrospective, and exploratory study design was employed.
• Medical records of 39 patients diagnosed with IgA deficiency were analyzed.

Main Results:

• Allergic rhinoconjunctivitis and allergic asthma were the primary clinical manifestations in both partial and total IgA deficiency.
• Patients with total IgA deficiency exhibited a statistically significant higher incidence of infection-related rhinosinusitis, tonsillitis, and conjunctivitis (p < 0.05).

Conclusions:

• The main clinical signs of IgA deficiency include allergic rhinoconjunctivitis and allergic asthma.
• Total IgA deficiency is associated with a significantly greater risk of specific infections compared to partial IgA deficiency.