Protein-based nanoparticles: From preparation to encapsulation of active molecules

Area of Science:

• Pharmaceutical Sciences
• Nanotechnology
• Materials Science

Background:

• Nanotechnology integration in pharmaceutical sciences offers advantages for drug delivery.
• Protein-based nanoparticles are crucial due to their non-toxic and biodegradable properties.
• Effective drug carriers are essential for advanced pharmaceutical applications.

Purpose of the Study:

• To review common preparation methods for protein nanoparticles.
• To discuss factors influencing protein nanoparticle dispersion.
• To highlight drug loading and release concepts for protein nanoparticles.

Main Methods:

• Literature review of protein nanoparticle preparation techniques.
• Analysis of factors affecting nanoparticle dispersion.
• Examination of drug loading and release mechanisms.

Main Results:

• Each preparation method can be optimized for specific proteins.
• Processing parameters significantly influence nanoparticle dispersion properties.
• Current literature supports various evidence-based methods.

Conclusions:

• Protein nanoparticle preparation requires method-specific optimization.
• Understanding processing parameters is key to controlling nanoparticle properties.
• Protein nanoparticles represent a promising platform for drug delivery systems.