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Splenic Hamartoma: Immunohistochemical Profile
Seyed Mohammad Tavangar1, Alireza Abdollahi2
1Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Splenic hamartoma, a benign spleen growth, can mimic other conditions. This case highlights its unique CD8, CD31, CD34, and CD68 biomarker positivity, aiding accurate diagnosis.
Area of Science:
- Pathology and Diagnostic Imaging
- Gastroenterology and Hepatology
Background:
- Splenic hamartoma is a rare, non-neoplastic splenic lesion.
- It can present incidentally due to mass effect on adjacent organs.
Observation:
- The case presented with abdominal pain, initially suspected as nephrolithiasis.
- Pathological examination revealed circumscribed, un-encapsulated nodules with fibrosis/cysts.
- Immunohistochemistry showed positivity for CD8, CD31, CD34, and CD68 on vascular cells.
Findings:
- Splenic hamartoma demonstrated characteristic histopathological features.
- Key diagnostic biomarkers included CD8 positivity, with occasional CD31, CD34, and CD68 expression.
- CD21 staining was notably negative, differentiating it from other splenic pathologies.
Implications:
- Accurate diagnosis of splenic hamartoma relies on integrating imaging and histopathology.
- Understanding specific biomarker profiles (CD8, CD31, CD34, CD68) is crucial for differentiation.
- This case underscores the importance of comprehensive evaluation for abdominal pain to avoid misdiagnosis.
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