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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

2.7K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Blood Typing01:10

Blood Typing

3.3K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
3.3K
The ABO Blood Group01:12

The ABO Blood Group

5.7K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
5.7K
Blood Types02:20

Blood Types

23.7K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Updated: Mar 7, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Blood Transfusion Therapy.

Lawrence Tim Goodnough1, Anil K Panigrahi2

  • 1Department of Pathology, Stanford University, Stanford, CA, USA; Department of Medicine, Stanford University, Stanford, CA, USA.

The Medical Clinics of North America
|February 13, 2017
PubMed
Summary
This summary is machine-generated.

Restrictive red blood cell (RBC) transfusion practices offer equivalent patient outcomes to liberal practices. This approach reduces mortality, cardiac events, and infections, improving blood utilization and minimizing inappropriate transfusions.

Keywords:
AnemiaClinical decision supportRed blood cell transfusionRestrictive transfusion practices

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Clinical Practice Guidelines

Background:

  • Red blood cell (RBC) transfusion is a critical medical intervention with inherent risks.
  • Balancing transfusion benefits against potential adverse events is essential for patient care.
  • Previous transfusion strategies often involved liberal transfusion thresholds.

Purpose of the Study:

  • To evaluate the efficacy and safety of restrictive red blood cell (RBC) transfusion practices.
  • To compare patient outcomes between restrictive and liberal RBC transfusion strategies.
  • To inform clinical decision-making regarding RBC transfusion thresholds.

Main Methods:

  • Analysis of randomized, controlled trials (RCTs) comparing restrictive versus liberal RBC transfusion.
  • Inclusion of meta-analyses synthesizing evidence from multiple RCTs.
  • Assessment of patient outcomes including mortality, cardiac events, and infections.

Main Results:

  • Restrictive RBC transfusion practices demonstrated equivalent patient outcomes compared to liberal practices.
  • Meta-analyses revealed significant reductions in in-hospital mortality with restrictive transfusion.
  • Evidence showed decreased cardiac events and bacterial infections in patients receiving restrictive RBC transfusions.

Conclusions:

  • Level 1 evidence supports restrictive RBC transfusion as a safe and effective strategy.
  • Implementation of restrictive transfusion guidelines improves blood utilization and reduces inappropriate transfusions.
  • Clinical decision support systems and education enhance the adoption of evidence-based transfusion practices.