Association between Systemic Diseases and Endodontic Outcome: A Systematic Review

Area of Science:

• Endodontics
• Systemic Health
• Evidence-Based Dentistry

Background:

• The association between systemic diseases and endodontic treatment outcomes is not well-established.
• Host-modifying factors require further investigation regarding their impact on endodontic success.

Purpose of the Study:

• To systematically review and evaluate the relationship between systemic diseases and endodontic outcomes.
• To assess the influence of host-modifying factors on the success rates of endodontic treatments.

Main Methods:

• Comprehensive literature search across multiple databases (MEDLINE, Embase, Cochrane, PubMed).
• Manual search of bibliographies and gray literature for relevant articles and textbooks.
• Independent review by two researchers with no disagreements.

Main Results:

• Sixteen articles met inclusion criteria, all with moderate to high risk of bias.
• Evidence is inconclusive regarding the association between diabetes/cardiovascular disease and endodontic outcomes.
• Human immunodeficiency virus and oral bisphosphonates did not show an association with endodontic outcomes.

Conclusions:

• The current scientific evidence on systemic diseases and endodontic outcomes is inconclusive.
• Some systemic diseases may be correlated with endodontic treatment results.
• Additional well-designed longitudinal clinical studies are necessary to clarify these relationships.