Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling time to visual insight in Mooney image recognition with a chaotic recurrent neural network.

Cognitive neurodynamics·2026
Same author

Singing Experience Influences RSST Scores.

Healthcare (Basel, Switzerland)·2022
Same author

Functional cortical localization of tongue movements using corticokinematic coherence with a deep learning-assisted motion capture system.

Scientific reports·2022
Same author

The Synergic Role of Actomyosin Architecture and Biased Detachment in Muscle Energetics: Insights in Cross Bridge Mechanism Beyond the Lever-Arm Swing.

International journal of molecular sciences·2021
Same author

Activation probability of a single naïve T cell upon TCR ligation is controlled by T cells interacting with the same antigen-presenting cell.

FEBS letters·2021
Same author

Ferroelectric Sr<sub>3</sub> Sn<sub>2</sub> O<sub>7</sub> :Nd<sup>3+</sup> : A New Multipiezo Material with Ultrasensitive and Sustainable Near-Infrared Piezoluminescence.

Advanced materials (Deerfield Beach, Fla.)·2020

Related Experiment Video

Updated: Mar 7, 2026

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
09:45

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells

Published on: February 9, 2012

26.0K

Single molecule detection, thermal fluctuation and life.

Toshio Yanagida1, Yoshiharu Ishii

  • 1Graduate School of Frontier Biosciences, Osaka University.

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
|February 14, 2017
PubMed
Summary
This summary is machine-generated.

Biological molecular machines harness thermal noise for movement and conformational changes, unlike artificial machines. Single molecule detection reveals their inherent flexibility and efficiency in biological processes.

More Related Videos

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
11:24

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

11.4K
Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

23.0K

Related Experiment Videos

Last Updated: Mar 7, 2026

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
09:45

Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells

Published on: February 9, 2012

26.0K
High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
11:24

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

11.4K
Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

23.0K

Area of Science:

  • Biophysics
  • Molecular Biology
  • Biochemistry

Background:

  • Single molecule detection techniques offer unprecedented insights into biological mechanisms.
  • Biological molecular machines exhibit unique operational principles compared to artificial constructs.

Purpose of the Study:

  • To elucidate how biological molecular machines utilize thermal fluctuations.
  • To compare the functional strategies of biological versus artificial machines.

Main Methods:

  • Utilizing single molecule detection to observe molecular dynamics.
  • Analyzing Brownian motion and conformational changes in protein molecules.

Main Results:

  • Demonstrated that myosin motors employ biased Brownian motion for directed movement.
  • Observed spontaneous protein conformational changes driven by thermal fluctuations.
  • Highlighted the integration of thermal noise as a key feature of biological machines.

Conclusions:

  • Biological molecular machines leverage thermal noise for flexibility and efficiency.
  • These findings underscore the distinct advantages of biological over artificial machinery.