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Study of High Sensitive C-Reactive Protein (HS-CRP) After Cardiac Rehabilitation Program in Patients Undergoing
Adel Johari Moghadam1, Saied Azizinejad1
1Department of Cardiology, AJA University of Medical Sciences, Tehran, Iran.
Insights
Cardiac rehabilitation significantly reduces high-sensitivity C-reactive protein (hs-CRP) levels in patients post-coronary artery bypass surgery. This 8-week program effectively lowers inflammation markers, indicating reduced cardiovascular risk.
Area of Science:
- Cardiology
- Biochemistry
- Preventive Medicine
Background:
- Cardiac rehabilitation is recognized for reducing cardiovascular complications.
- The impact of cardiac rehabilitation on high-sensitivity C-reactive protein (hs-CRP), a key inflammation and cardiovascular risk marker, requires further investigation.
Purpose of the Study:
- To investigate the effect of an 8-week conventional cardiac rehabilitation program on hs-CRP levels.
- To assess hs-CRP changes in patients who underwent isolated coronary artery bypass surgery (CABGS).
Main Methods:
- A case study involving 30 patients undergoing isolated CABGS who completed an 8-week cardiac rehabilitation program.
- A control group of 30 similar patients not participating in the rehabilitation program.
- Retrospective measurement of serum hs-CRP levels before and after the 8-week intervention period.
Main Results:
- Initial hs-CRP levels were comparable between the rehabilitation and control groups (P=0.833).
- After the 8-week program, hs-CRP levels significantly decreased in the rehabilitation group (2.3 ± 5.1) compared to the control group (5.7 ± 6.1) (P=0.023).
- The reduction in hs-CRP was statistically significant in the rehabilitation group (P=0.037) but not in the control group (P=0.0723).
Conclusions:
- An 8-week cardiac rehabilitation program significantly reduces hs-CRP levels in patients post-coronary artery bypass surgery.
- Cardiac rehabilitation effectively lowers inflammation markers, contributing to reduced cardiovascular risk.
Introduction:
Although cardiac rehabilitation is known as a tool to reduce the overall risk of cardiovascular complications, its specific role in the reduction of hs-CRP as a marker of inflammation and a proven marker of cardiovascular risk needs further investigation.
Aim:
The present study aims at elucidating the effects of a full course of conventional cardiac rehabilitation program for the period of eight weeks, on the levels of hs-CRP in patients who underwent isolated coronary artery bypass surgery.
Material And Methods:
In this case study, 30 consecutive patients who underwent isolated coronary artery bypass surgery (isolated CABGS), and a full 8-week cardiac rehabilitation program in Tehran Heart Center, were investigated. A group of 30 similar patients, who enrolled in the same period of rehabilitation program but did not participate in practice, was considered as a control group. Serum levels of hs-CRP in both groups were measured retrospectively and in similar days before the start of rehabilitation program and at the end of it (or 8 weeks after initial registration for the control group).
Results:
Levels of hs-CRP in the rehabilitation group and control group were 5.9 7.7 and 6.3 6.9 respectively before start of the program which was not statistically meaningful (P-Value = 0.833). However, after the program, level of hs-CRP in the two tested groups changed to 2.3 5.1 and 5.7 6.1 respectively which showed a meaningful correlation (P-Value = 0.023). These results also showed that decrease in hs-CRP level in the rehabilitated group but not in the control group was statistically meaningful (with P-Value of 0.037 and 0.0723 respectively).
Conclusion:
In patients undergoing coronary bypass surgery, participating in a full course of cardiac rehabilitation for 8 weeks has resulted in a significant reduction in hs-CRP levels as a marker of cardiovascular risk.
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