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Experimental Approaches for Eliminating Latent HIV
Matthew D Marsden1, Jerome A Zack2
1Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, CA.
Forum on Immunopathological Diseases and Therapeutics
|February 14, 2017
Summary
Antiretroviral therapy (ART) controls HIV but doesn't eliminate latent reservoirs. Research explores methods like gene therapy and "shock and kill" to eradicate the virus for an HIV cure.
Area of Science:
- Virology
- Immunology
- Gene Therapy
Background:
- Antiretroviral therapy (ART) effectively suppresses HIV but does not eliminate latent viral reservoirs.
- Latently infected CD4+ T cells harbor persistent HIV, enabling viral rebound upon ART cessation.
Purpose of the Study:
- To review experimental strategies for eradicating latent HIV reservoirs.
- To discuss advancements in HIV cure research focusing on eliminating persistent virus.
Main Methods:
- Investigating transplantation and gene therapy to replace HIV-infected cells with resistant ones.
- Exploring DNA editing to excise or damage latent HIV proviruses.
- Examining "shock and kill" approaches to induce latent virus expression for elimination.
Main Results:
- Multiple experimental approaches show promise for targeting latent HIV reservoirs.
- Advances in gene editing and immune-based strategies are key areas of development.
Conclusions:
- A definitive HIV cure requires strategies to eliminate or inactivate latent viral reservoirs.
- Ongoing research into novel therapeutic approaches offers hope for eradicating persistent HIV.
