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Updated: Mar 7, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

"En face" OCT in Small Pigmented Choroidal Tumors.

S Cotting-Bodmer¹, L Zografos¹, A Schalenbourg¹

¹Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, FAA, Lausanne, Switzerland.

Klinische Monatsblatter Fur Augenheilkunde

|February 14, 2017

Summary

En face optical coherence tomography (OCT) reveals characteristic patterns in small pigmented choroidal tumors. This imaging technique helps define tumor features and margins more precisely than traditional methods.

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Area of Science:

Ophthalmology
Medical Imaging
Oncology

Background:

En face optical coherence tomography (OCT) provides cross-sectional views parallel to the retinal pigment epithelium (RPE).
Evaluating small pigmented choroidal tumors requires precise imaging techniques.
Spectral domain OCT is utilized for detailed analysis.

Purpose of the Study:

To define the utility of en face OCT in assessing small pigmented choroidal tumors.
To analyze the morphological characteristics of these tumors using en face OCT.

Main Methods:

Investigated 27 small pigmented choroidal tumors using en face OCT.
Performed manual segmentation and selected spectral domain OCT sections at 30, 80, and 130 µm beneath the RPE.
Conducted morphological and statistical analysis of the selected images.

Main Results:

Tumor internal reflectance varied (hyper-, iso-, or hypo-reflective) with uniform or bull's eye patterns.
Reflectance decreased towards the tumor center.
Tumor margins appeared similar to or less extensive than ophthalmoscopic findings.
Peritumoral vascularization became distinct from the 80 µm section downwards.

Conclusions:

En face OCT demonstrates uniform or bull's eye internal reflectance in small pigmented choroidal tumors.
Tumor intensity is variable relative to the surrounding choroid.
Tumor margins may appear more confined on en face OCT compared to color fundus photography.