An artificial neural networks approach for assessment treatment response in oncological patients using PET/CT images
Mariana A Nogueira1, Pedro H Abreu2, Pedro Martins1
1CISUC - Department of Informatics Engineering - University of Coimbra, - Pólo II Pinhal de Marrocos, Coimbra, 3030-290, Portugal.
Background:
Positron Emission Tomography - Computed Tomography (PET/CT) imaging is the basis for the evaluation of response-to-treatment of several oncological diseases. In practice, such evaluation is manually performed by specialists, which is rather complex and time-consuming. Evaluation measures have been proposed, but with questionable reliability. The usage of before and after-treatment image descriptors of the lesions for treatment response evaluation is still a territory to be explored.
Methods:
In this project, Artificial Neural Network approaches were implemented to automatically assess treatment response of patients suffering from neuroendocrine tumors and Hodgkyn lymphoma, based on image features extracted from PET/CT.
Results:
The results show that the considered set of features allows for the achievement of very high classification performances, especially when data is properly balanced.
Conclusions:
After synthetic data generation and PCA-based dimensionality reduction to only two components, LVQNN assured classification accuracies of 100%, 100%, 96.3% and 100% regarding the 4 response-to-treatment classes.
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