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Pathophysiology and treatment of atherosclerosis : Current view and future perspective on lipoprotein modification

S C Bergheanu1,2, M C Bodde3, J W Jukema4

  • 1Centre for Human Drug Research, Leiden, The Netherlands.

Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
|February 15, 2017
PubMed

Insights

This review covers new findings in atherosclerosis, focusing on how lipoprotein particles like LDL-C, HDL-C, TG, and Lp(a) contribute to plaque formation and how new drugs target these pathways.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Pharmacology

Background:

  • Atherosclerosis pathogenesis and current treatment strategies are evolving.
  • Understanding lipoprotein particle roles in plaque formation is improving.
  • Recent clinical trials offer insights into novel therapeutic agents.

Purpose of the Study:

  • To review current knowledge on atherosclerosis pathophysiology and treatment.
  • To discuss emerging drug classes targeting atherosclerosis.
  • To focus on key lipid targets: LDL-C, HDL-C, TG, and Lp(a).

Main Methods:

  • Literature review of recent findings in atherosclerosis.
  • Analysis of cardiovascular clinical trial data.
  • Synthesis of current understanding and future perspectives on novel therapies.

Main Results:

  • Enhanced understanding of lipoprotein particle involvement in atherosclerotic plaque development.
  • Evaluation of the efficacy and safety of novel compounds targeting atherosclerosis pathways.
  • Identification of key lipid targets for therapeutic intervention.

Conclusions:

  • Novel therapeutic strategies targeting specific lipoproteins show promise for managing atherosclerosis.
  • Continued research into lipid metabolism and cardiovascular complications is crucial.
  • Personalized medicine approaches may optimize treatment for atherosclerotic disease.
Keywords:
AtherosclerosisCardiovascular diseaseHypercholesterolaemiaLow-density lipoproteinProprotein convertase subtilisin/kexin type-9Statins

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