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Glucose-Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid
Ali K Yetisen1,2,3, Nan Jiang2,3,4, Afsoon Fallahi2,3
1Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
Abstract:
Hydrogel optical fibers are utilized for continuous glucose sensing in real time. The hydrogel fibers consist of poly(acrylamide-co-poly(ethylene glycol) diacrylate) cores functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis-diol groups of glucose enables reversible changes of the hydrogel fiber diameter. The analyses of light propagation loss allow for quantitative glucose measurements within the physiological range.

