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Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

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Optical Contact Lenses Biosensors.

Xiaoye Xia¹, Yubing Hu¹, Nan Jiang^2,3

¹Department of Chemical Engineering, Imperial College London, South Kensington, London SW7 2BU, U.K.

|October 2, 2025

Summary

Contact lens biosensors offer noninvasive monitoring of tear fluid biomarkers for early disease detection. Advances in materials and optical sensing enable real-time analysis for personalized healthcare.

Keywords:

contact lens sensor microfabrication techniques neurodegenerative diseases ocular diseases optical biosensing

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Development of an In Vitro Ocular Platform to Test Contact Lenses

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Published on: April 6, 2016

Area of Science:

Biomedical Engineering
Ophthalmology
Analytical Chemistry

Background:

Tear fluid analysis offers noninvasive diagnostics for ocular and systemic health.
Contact lens biosensors integrate optical sensing for real-time tear fluid monitoring.

Purpose of the Study:

To review recent advances in contact lens biosensors for optical detection of tear-based biomarkers.
To highlight the potential of these sensors in diagnosing and monitoring various diseases.

Main Methods:

Utilizing biocompatible hydrogel and silicone hydrogel materials.
Employing fabrication techniques like inkjet printing and 3D microfabrication.
Integrating optical sensing mechanisms such as fluorescence and surface plasmon resonance.

Main Results:

High sensitivity detection of glucose, lactate, electrolytes, cortisol, and inflammatory markers.
Demonstrated potential in diagnosing diabetes, dry eye syndrome, and stress-related disorders.
Identified challenges including background interference and multiplexed detection limitations.

Conclusions:

Contact lens biosensors are a promising platform for personalized healthcare via noninvasive tear analysis.
Future research should focus on robust chemistries, wireless readouts, and scalable manufacturing for clinical translation.