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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Clinical Features and Management of Subretinal Abscesses Secondary to Methicillin-Resistant Staphylococcus aureus

Jorge Fortun, Yasha S Modi, Angela Bessette

    Ophthalmic Surgery, Lasers & Imaging Retina
    |February 15, 2017
    PubMed
    Abstract

    Insights

    Prompt diagnosis and systemic antibiotic therapy are crucial for treating subretinal abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA) endogenous endophthalmitis, leading to abscess consolidation.

    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Microbiology

    Background:

    • Investigating subretinal abscesses as a rare manifestation of endogenous endophthalmitis.
    • Focusing on cases caused by methicillin-resistant Staphylococcus aureus (MRSA).

    Observation:

    • Retrospective review of eleven eyes from seven patients with MRSA endogenous endophthalmitis.
    • Noting a history of recurrent MRSA infections or active skin ulcerations in some patients.
    • Vitreous and blood cultures were analyzed for MRSA identification.

    Findings:

    • Subretinal abscesses were observed in eleven eyes secondary to MRSA endogenous endophthalmitis.
    • Systemic and intravitreal vancomycin were primary treatment modalities.
    • Abscess consolidation occurred rapidly following initiation of antibiotic therapy.
    • Visual outcomes depended on abscess location and treatment timeliness.

    Implications:

    • Highlights the importance of prompt diagnosis and systemic antibiotic treatment for this condition.
    • Emphasizes the role of vancomycin in managing MRSA endophthalmitis.
    • Suggests that early intervention improves visual prognosis in subretinal abscesses.

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