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In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches

H Lennernäs1, A Lindahl2, A Van Peer3

  • 1Department of Pharmacy, Uppsala University , Uppsala, Sweden.

Molecular Pharmaceutics
|February 15, 2017
PubMed
Summary

The OrBiTo project is developing biopharmaceutics tools to optimize oral drug development. Combining in vitro dissolution tests and in silico models enhances gastrointestinal absorption predictions for regulatory use.

Keywords:
Biopharmaceutics Classification SystemPBPKbioequivalencebiorelevant dissolutiongeneric drugsin vivo predictive dissolutionintestinal drug absorptiontheoretical modeling

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