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Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum
Janaína Artem Ataide1, Letícia Caramori Cefali2, Marcia de Araujo Rebelo3
1Postgraduate Program in Medical Sciences, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
Planta Medica
|February 15, 2017
Summary
This study developed a novel hydrogel wound dressing using alginate and Arabic gum to deliver bromelain. This innovative hydrogel promotes effective wound healing by maintaining a moist environment and aiding tissue repair.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Drug Delivery Systems
Background:
- Ideal wound dressings maintain a moist environment and absorb exudates.
- Bromelain application aids wound healing by reprogramming the microenvironment.
- Combining hydrogels with bromelain offers significant therapeutic potential.
Purpose of the Study:
- To develop and characterize a novel hydrogel formulation for bromelain loading and controlled release.
- To optimize hydrogel composition using response surface methodology.
- To evaluate bromelain immobilization and release kinetics within the hydrogel matrix.
Main Methods:
- Hydrogel formulation using alginate and Arabic gum.
- Response surface methodology for optimization (pH, alginate, Arabic gum concentrations).
- Differential scanning calorimetry and Fourier transform infrared spectroscopy for bromelain immobilization analysis.
- Passive diffusion method for evaluating bromelain release.
Main Results:
- Optimized hydrogel formulation achieved a 227% swelling ratio.
- Successfully incorporated 19% of bromelain into the hydrogel matrix.
- Bromelain immobilization confirmed via hydrogen bonding, optimal at 4°C after 4 hours.
Conclusions:
- Entrapment of bromelain within an alginate-Arabic gum hydrogel is a viable strategy.
- This hydrogel system shows promise for advanced wound dressings.
- Potential application in debridement of burns and wounds, promoting effective tissue repair.
