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Updated: Mar 7, 2026
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
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Pathways, perspectives and pursuits in polycystic kidney disease
L V K S Bhaskar1, Ramprasad Elumalai2, Soundararajan Periasamy2
1Sickle Cell Institute Chhattisgarh, Raipur, India.
Journal of Nephropharmacology
|February 16, 2017
Summary
Polycystic kidney disease (PKD) involves kidney cyst growth, impairing function and potentially causing failure. Research, particularly using mouse models, is uncovering genetic pathways and therapeutic targets for this condition.
Area of Science:
- Nephrology
- Genetics
- Molecular Biology
Background:
- Polycystic kidney disease (PKD) is a genetic disorder characterized by renal cyst formation.
- Cysts enlarge kidneys, replacing normal tissue, reducing function, and potentially leading to kidney failure.
- Autosomal dominant polycystic kidney disease (ADPKD) affects 1 in 1000 individuals.
Purpose of the Study:
- To review the current understanding of PKD etiopathology.
- To explore the genetic pathways involved in PKD pathogenesis.
- To identify potential therapeutic targets for slowing PKD progression.
Main Methods:
- Analysis of human population studies.
- Utilizing animal models, particularly mouse models, to study PKD.
- Review of existing literature on PKD gene pathways and signaling molecules.
Main Results:
- Mouse models have significantly advanced the understanding of PKD pathogenesis.
- Key gene pathways and tissue-specific signaling molecules critical for cyst development have been identified.
- PKD presents unique challenges for therapeutic development.
Conclusions:
- Continued research into PKD pathogenesis is crucial.
- Understanding genetic pathways and signaling molecules is key to developing effective therapies.
- Targeting specific pathways offers promise for slowing PKD progression.
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