Spectrum of medical renal pathological findings in tumor nephrectomy specimens: A multicenter study from India

Pathologic changes in the non-neoplastic renal parenchyma of tumor nephrectomy specimens may have significant implications for patient outcomes.

The purpose of the present study is to analyze the spectrum of non-neoplastic pathologic findings in tumor nephrectomy specimens and to correlate with the clinical findings.

We conducted a multicenter retrospective study and examined the non-neoplastic renal parenchymal changes in 168 tumor nephrectomy specimens. The presence of glomerular, tubulointerstitial, and vascular pathology was noted, and we correlated the findings with the patient's clinical information. Serum creatinine levels were recorded preoperatively, at 3 months, and at 6 months postoperative period.

In our study, pathologic findings in the non-neoplastic renal parenchyma were identified in 29.7% of the cases, and diabetic nephropathy was the most frequent finding, accounting for 20.8% of the cases. Among the cases of diabetic nephropathy, 77.1% showed features of early diabetic nephropathy with diffuse mesangial sclerosis, and there was a significant increase in serum creatinine in these cases ( P = 0.009) from the preoperative period to 6 months postoperatively.

Adequate examination of the non-neoplastic renal parenchyma is an important tool for identifying patients at risk of developing progressive renal disease after nephrectomy. This allows the opportunity to provide early preventive and treatment measures and better outcomes for patients undergoing nephrectomy for neoplastic processes.