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Updated: Mar 7, 2026
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
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Deciphering tumor heterogeneity from FFPE tissues: Its promise and challenges
1Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine , Nashville, TN, USA.
Molecular & Cellular Oncology
|February 16, 2017
Abstract:
An impediment to the understanding of cancer is the heterogeneous nature of cell populations within a tumor microenvironment. We reported a method to query protein signaling in single epithelial cells from formalin-fixed paraffin-embedded (FFPE) colorectal cancer tissues. Here, we discuss the feasibility and limitations of this approach for investigating signaling state heterogeneity.
Keywords:
Colorectal cancerFFPEdisaggregationepithelial cellsmass cytometrysignal transductionsingle cellsolid tissuessystems biologytumor heterogeneity
