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Related Experiment Video

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A constrained slice-dependent background suppression scheme for simultaneous multislice pseudo-continuous arterial

Xingfeng Shao1, Yi Wang2, Steen Moeller3

  • 1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Soutern California, Los Angeles, California, USA.

Magnetic Resonance in Medicine
|February 16, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a new constrained slice-dependent background suppression technique for 2D arterial spin labeling. The method significantly improves signal-to-noise ratio and enables whole-brain perfusion imaging.

Keywords:
arterial spin labeling (ASL)background suppression (BS)controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA)simultaneous multislice (SMS)

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Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Neuroimaging

Background:

  • Background suppression in 2D arterial spin labeling (ASL) is complex due to multiple nulling points.
  • Simultaneous multislice (SMS) acquisition offers potential for faster 2D imaging.
  • Optimizing background suppression in accelerated 2D ASL remains a challenge.

Purpose of the Study:

  • To introduce and evaluate a constrained slice-dependent (CSD) background-suppression (BS) scheme for 2D ASL.
  • To leverage SMS acquisition with blipped-CAIPIRINHA for enhanced ASL imaging.
  • To improve background signal suppression and signal-to-noise ratio in accelerated 2D ASL.

Main Methods:

  • Developed a CSD BS scheme utilizing SMS to shorten readout duration.
  • Employed slice-dependent premodulation pulses for BS across slice groups.
  • Validated the CSD BS scheme in vivo at 3 Tesla with multiband acceleration factors up to 4.
  • Compared CSD BS against standard 2D ASL and 3D BS pseudo-continuous ASL (pCASL).

Main Results:

  • Achieved an average of 95% background signal reduction with CSD BS.
  • Reported significant increases in temporal SNR (up to 48.2%) and spatial SNR (up to 132.5%) with CSD BS.
  • Demonstrated whole-brain coverage with CSD BS pCASL at MB-4, comparable in spatial SNR to 3D BS pCASL.

Conclusions:

  • The CSD BS scheme for 2D-SMS pCASL effectively suppresses background signals.
  • This technique facilitates whole-brain perfusion imaging across a wide range of T1 values.
  • CSD BS presents a promising advancement for accelerated 2D ASL neuroimaging.