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Genital nerve stimulation increases bladder capacity after SCI: A meta-analysis.

Dennis J Bourbeau1,2,3, Graham H Creasey4,5, Steven Sidik3,6

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|February 16, 2017
PubMed
Summary
This summary is machine-generated.

Electrical stimulation of the genital nerves (GNS) significantly increases bladder capacity in individuals with neurogenic detrusor overactivity (NDO). This intervention shows promise for improving bladder function in NDO patients.

Keywords:
Electrical stimulationGenital nerve stimulationNeurogenic bladderSpinal cord injury

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Area of Science:

  • Urology
  • Neuroscience

Background:

  • Neurogenic detrusor overactivity (NDO) leads to reduced bladder capacity and incontinence.
  • NDO can cause autonomic dysreflexia and negatively impact quality of life.

Purpose of the Study:

  • To quantify the effect of electrical stimulation of the genital nerves (GNS) on bladder capacity in NDO patients.
  • To identify study and subject factors influencing bladder capacity improvements with GNS.

Main Methods:

  • A meta-analysis was performed on data from 97 individuals across eight studies.
  • Bladder capacity was measured with and without GNS in individuals with NDO.

Main Results:

  • GNS increased bladder capacity by 131±101 ml across all subjects.
  • The proportion of individuals with bladder capacity >300 ml increased from 24% to 62% with GNS.
  • Stimulus amplitude was a significant predictor of capacity gain, while infusion rate affected variance.

Conclusions:

  • GNS acutely enhances bladder capacity in NDO patients.
  • The consistent positive effects suggest GNS is a potentially effective tool for NDO.
  • Further research on chronic GNS effects and urinary continence is warranted.