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Updated: Mar 7, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Decreased Cingulate Cortex activation during cognitive control processing in bipolar disorder.

Staci A Gruber1, M Kathryn Dahlgren2, Kelly A Sagar1

  • 1Cognitive and Clinical Neuroimaging Core, McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, United States.

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|February 16, 2017
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Summary
This summary is machine-generated.

Bipolar disorder patients show impaired cognitive control, evidenced by lower accuracy and different brain activation patterns in the cingulate and prefrontal cortex during a task. This highlights potential neural targets for cognitive remediation.

Keywords:
Bipolar disorderCognitive controlExecutive functionMSITMulti-Source Interference TaskfMRI

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Cognitive deficits are common in bipolar disorder (BPD), potentially hindering psychotherapy effectiveness.
  • Cognitive control, a key executive function, is crucial for managing thoughts and behaviors.
  • Therapeutic interventions often aim to improve cognitive control for adaptive coping.

Purpose of the Study:

  • To investigate cognitive control processing in individuals with BPD.
  • To compare cognitive control performance and neural activity between BPD patients and healthy controls (HC).

Main Methods:

  • Utilized the Multi-Source Interference Task (MSIT) to assess cognitive control.
  • Employed functional magnetic resonance imaging (fMRI) to capture brain activity during the MSIT.
  • Included 29 BPD patients and 21 HC participants.

Main Results:

  • BPD patients exhibited poorer performance on the MSIT, with lower accuracy and more omission errors compared to HC.
  • fMRI revealed distinct brain activation patterns: reduced activation in the cingulate cortex (CC) and increased activation in the prefrontal cortex (PFC) in the BPD group.
  • While PFC findings were not statistically robust, CC differences were significant.

Conclusions:

  • Impaired cognitive control in BPD may be linked to reduced CC and increased PFC activation during tasks like the MSIT.
  • Understanding these neural mechanisms is vital for clarifying BPD pathophysiology.
  • Identifying neural targets could inform the development of cognitive remediation strategies for BPD.