Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Mitotic Spindle02:27

The Mitotic Spindle

8.2K
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
8.2K
Spermatogenesis01:41

Spermatogenesis

124.2K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
124.2K
Spermatogenesis01:22

Spermatogenesis

10.3K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
10.3K
Spindle Assembly02:50

Spindle Assembly

4.4K
Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
4.4K
Anaphase A and B01:39

Anaphase A and B

5.7K
Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
5.7K
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

6.9K
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cooperative B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>/Chiral Secondary Amine-Catalyzed Asymmetric [4 + 2] Cycloaddition Reaction.

Organic letters·2026
Same author

Divergent Site-Selective Coupling of Benzothiophenes via a Dearomative Halogenation Platform.

Organic letters·2026
Same author

Systematic Abductive Reasoning via Diverse Relation Representations in Vector-Symbolic Architecture.

IEEE transactions on neural networks and learning systems·2026
Same author

Early Clinical Symptom Patterns Predict the Subsequent Treatment Response of Patients with Acute Schizophrenia.

Schizophrenia bulletin·2026
Same author

Synergistic effect of rubber powder and nano-silica on pore structure and frost resistance of concrete.

Scientific reports·2026
Same author

[Electroacupuncture alleviates anxiety-like behavior in PTSD rats via modulating glycolysis/H4K12la/HIF-1α signaling pathway].

Zhen ci yan jiu = Acupuncture research·2026
Same journal

Reduced Circulating Polyamines in Polyendocrine Metabolic Ovarian Syndrome (PMOS) Patients and the Impact of Putrescine on Ovarian Function and Fertility in a Murine PMOS Model.

Biology of reproduction·2026
Same journal

DEVELOPMENTAL PROGRAMMING IN DOGS.

Biology of reproduction·2026
Same journal

Meiosis-Specific Cohesin in Mammalian Germ Cells.

Biology of reproduction·2026
Same journal

The Research of Lactylation in the Field of Reproduction.

Biology of reproduction·2026
Same journal

Mitochondria as Integrative Regulators of Ferroptosis in the Female Reproductive System.

Biology of reproduction·2026
Same journal

Navigation of Nanos germ cell specification factor to germ granules-posttranscriptional regulation hubs-across species†.

Biology of reproduction·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry
09:41

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry

Published on: December 28, 2021

2.3K

Kinesins in spermatogenesis.

Dan-Dan Ma1, Da-Hui Wang2, Wan-Xi Yang1

  • 1The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China.

Biology of Reproduction
|February 17, 2017
PubMed
Summary
This summary is machine-generated.

Kinesins are vital for cell division and sperm development. Specific kinesin families ensure accurate chromosome segregation and sperm maturation, highlighting their crucial roles in male reproduction.

Keywords:
kinesinsmitosismeiosisspermiogenesistranscription

More Related Videos

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

16.0K
Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.5K

Related Experiment Videos

Last Updated: Mar 7, 2026

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry
09:41

Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry

Published on: December 28, 2021

2.3K
A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
09:40

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model

Published on: February 6, 2018

16.0K
Imaging Centrosomes in Fly Testes
09:41

Imaging Centrosomes in Fly Testes

Published on: September 20, 2013

16.5K

Area of Science:

  • Cell Biology
  • Reproductive Biology
  • Molecular Motors

Background:

  • Kinesins are crucial motor proteins for polar cell function, including in sperm development.
  • Spermatogenesis involves complex processes like cell division, organelle transport, and sperm structure formation, all reliant on kinesins.

Purpose of the Study:

  • To review the diverse roles of kinesins throughout mitosis, meiosis, and spermiogenesis.
  • To identify specific kinesin members involved in key stages of sperm formation and maturation.

Main Methods:

  • Literature review of studies on kinesin function in cell division and spermatogenesis.
  • Analysis of reported kinesin involvement in chromosome segregation, organelle transport, and sperm morphogenesis.

Main Results:

  • Kinesin-13, kinesin-8, and chromokinesins are essential for sister chromatid congression and segregation during meiosis.
  • Specific kinesins (e.g., KIFC1, KIF5C, KIF17b, KIF3A) are implicated in acrosome biogenesis, nuclear shaping, and tail formation.
  • KIF17b shows postmeiotic transcriptional activity crucial for sperm structural changes.

Conclusions:

  • Kinesins play indispensable roles in ensuring the successful completion of meiosis and spermiogenesis.
  • Further research is needed to fully elucidate the functions of various kinesins in sperm development and identify critical areas for future investigation.