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Published on: September 19, 2010
Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals
Markella V Zanni1, Mabel Toribio1, Moses Q Wilks2
1Program in Nutritional Metabolism and.
Background:
The ability to noninvasively assess arterial CD206+ macrophages may lead to improved understanding of human immunodeficiency virus (HIV)-associated cardiovascular disease.
Methods:
We trialed a novel macrophage-specific arterial imaging technique.
Results:
We demonstrated colocalization between technetium Tc 99m tilmanocept (99mTc-tilmanocept) and CD206+ macrophages ex vivo. In vivo application of 99mTc-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level 99mTc-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non-HIV-infected subjects (P = .009). Among all subjects, aortic high-level 99mTc-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P = .003) on computed tomographic angiography, and this relationship held when we controlled for HIV status.
Conclusion:
These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV.
Clinical Trials Registration:
NCT02542371.
