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Updated: Mar 7, 2026

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model
Published on: April 28, 2023
Total proximal ureter substitution using buccal mucosa.
Omar Fahmy1, Tina Schubert2, Mohd Ghani Khairul-Asri1
1Department of Urology, University of Putra Malaysia, Selangor, Malaysia.
Buccal mucosa grafting offers a promising, low-morbidity solution for complex long ureteral strictures. This surgical technique shows potential for successful ureteral reconstruction in select patients.
Area of Science:
- Urology
- Surgical Innovation
- Regenerative Medicine
Background:
- Long proximal ureteral strictures pose significant reconstructive challenges.
- Existing treatments like ileal interposition and autotransplantation have limitations.
- Buccal mucosa is well-established in urethroplasty but rarely used for ureteral reconstruction.
Observation:
- A 64-year-old female patient with Crohn's disease and comorbidities presented with a long proximal ureteral stricture.
- She underwent successful total ureteral substitution using buccal mucosa.
- Postoperative isotope scans demonstrated improved renal function.
Findings:
- Buccal mucosa grafting achieved successful total substitution of a long proximal ureteral segment.
- The procedure resulted in improved renal function post-surgery.
- This case highlights the potential of buccal mucosa in complex ureteral reconstruction.
Implications:
- Buccal mucosa may be a viable, low-morbidity alternative for select ureteral reconstruction cases.
- Further research into buccal mucosa for ureteral repair is warranted.
- This approach could expand reconstructive options for challenging ureteral strictures.
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