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Updated: Mar 7, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Clustering determines the dynamics of complex contagions in multiplex networks
Yong Zhuang1, Alex Arenas2, Osman Yağan1
1Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
We analyzed complex contagions in clustered multiplex networks. Higher clustering generally reduces cascade spread, but this effect reverses at higher average network degrees, revealing complex dynamics.
Area of Science:
- Network Science
- Mathematical Modeling
- Complex Systems
Background:
- Understanding contagion spread (e.g., influence, information) in interconnected networks is crucial.
- Multiplex networks, with multiple layers of connections, offer a more realistic representation of complex systems.
- Threshold dynamics models explain how individual adoption depends on a fraction of neighbors adopting.
Purpose of the Study:
- To mathematically analyze generalized complex contagions in clustered multiplex networks.
- To investigate the impact of network clustering and link diversity on contagion spread.
- To generalize existing models for content-dependent linear threshold dynamics.
Main Methods:
- Utilized the generating functions formalism for mathematical analysis.
- Developed a generalized linear threshold model accounting for content-dependent link weights.
- Examined conditions, probability, and expected size of global cascades.
Main Results:
- Identified nontrivial dependencies between clustering coefficient and average degree.
- Observed phase transitions in contagion spread based on network descriptors.
- Found that increasing clustering typically decreases cascade probability and size, but this trend reverses at higher average degrees.
Conclusions:
- Network clustering has a complex, degree-dependent effect on contagion spread in multiplex networks.
- Ignoring link types and aggregating network layers can lead to inaccurate contagion dynamics predictions.
- The findings offer a generalized framework for studying spreading phenomena and percolation in complex networks.
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