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ERRγ: a Junior Orphan with a Senior Role in Metabolism
Jagannath Misra1, Don-Kyu Kim2, Hueng-Sik Choi1
1National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.
Trends in Endocrinology and Metabolism: TEM
|February 18, 2017
Summary
Estrogen-related receptor gamma (ERRγ) is a key regulator of metabolic signals and energy homeostasis. Targeting ERRγ offers a promising therapeutic strategy for metabolic diseases like insulin resistance.
Area of Science:
- Endocrinology
- Molecular Biology
- Metabolism
Background:
- Estrogen-related receptor gamma (ERRγ) is an orphan nuclear receptor.
- Its activity is ligand-independent, modulated by co-regulators and post-translational modifications (PTMs).
- ERRγ is implicated in various endocrine and metabolic processes.
Purpose of the Study:
- To elucidate the role of ERRγ in metabolic homeostasis.
- To evaluate ERRγ as a therapeutic target for metabolic disorders.
Main Methods:
- Analysis of data from animal models.
- Investigation of ERRγ's role in key metabolic tissues (heart, skeletal muscle, pancreatic β cells).
Main Results:
- ERRγ acts as a crucial mediator of endocrine and metabolic signals.
- It plays significant roles in pathological conditions including insulin resistance, alcoholic liver injury, and cardiac hypertrophy.
- ERRγ regulates energy metabolism in the heart, skeletal muscle, and pancreatic β cells.
Conclusions:
- ERRγ is vital for maintaining metabolic homeostasis.
- ERRγ represents a promising therapeutic target for treating metabolic diseases.
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