Photochemotherapy For Psoriasis with Psoralen and Sunlight.

Area of Science:

• Dermatology
• Phototherapy
• Pharmacology

Background:

• Psoriasis is a chronic inflammatory skin condition.
• Current treatments have limitations, necessitating exploration of alternative therapies.

Purpose of the Study:

• To evaluate the efficacy and safety of systemic psoralen and sunlight exposure therapy for psoriasis.

Main Methods:

• A double-blind study was conducted.
• Patients received oral psoralen followed by controlled sunlight exposure.
• Evaluation included clinical assessment, patient-reported outcomes, severity scores, and histopathology.

Main Results:

• 66.7% of patients experienced complete clearance of psoriatic lesions within 21 to 56 days.
• 33.3% of patients showed moderate improvement.
• The treatment was found to be safe and effective.

Conclusions:

• Systemic psoralen and sunlight exposure is a safe and effective treatment for psoriasis.
• This therapeutic approach can be recommended for routine management of psoriatic patients.