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Flavoalkaloids-Isolation, Biological Activity, and Total Synthesis
Lachlan M Blair1, Matthew B Calvert1, Jonathan Sperry1
1University of Auckland, Auckland, New Zealand.
The Alkaloids. Chemistry and Biology
|February 19, 2017
Summary
Flavoalkaloids, combining flavonoid and alkaloid structures, exhibit unique biological activities. This review summarizes known flavoalkaloids, their isolation, bioactivity, and synthesis up to early 2016.
Area of Science:
- Natural Product Chemistry
- Organic Chemistry
- Medicinal Chemistry
Background:
- Flavoalkaloids are hybrid natural products merging flavonoid and alkaloid structural features.
- Their unique molecular architecture arises from the convergence of distinct biosynthetic pathways.
- These compounds display a broader spectrum of biological activities than either parent class alone.
Purpose of the Study:
- To provide a comprehensive review of known flavoalkaloids.
- To detail the isolation, bioactivity, and synthetic strategies for these compounds.
- To cover literature up to early 2016.
Main Methods:
- Literature review and collation of existing data.
- Analysis of isolation and characterization methods for flavoalkaloids.
- Summary of reported biological activities and total synthesis approaches.
Main Results:
- Compilation of flavoalkaloids identified up to early 2016.
- Overview of diverse biological activities, including those not typical for flavonoids or alkaloids.
- Documentation of successful total syntheses, highlighting synthetic challenges and achievements.
Conclusions:
- Flavoalkaloids represent a unique class of natural products with significant potential.
- Understanding their biosynthesis and chemistry is crucial for drug discovery.
- This review serves as a foundational resource for future research in flavoalkaloid chemistry and applications.
