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Published on: October 18, 2021
[Zygomatic localization of Langerhans cell histiocytosis - a case report]
Barbara Rybus-Kalinowska1, Mariusz Kalinowski2, Bogna Teodorowicz-Rachuba3
1Katedra i Zakład Podstawowych Nauk Medycznych, Wydział Zdrowia Publicznego w Bytomiu, Śląski Uniwersytet Medyczny w Katowicach, Polska, Chorzowskie Centrum Pediatrii i Onkologii, Chorzów, Polska.
Insights
Langerhans cell histocytosis (LCH) is a rare condition. This case study details a 17-month-old boy with multisystem LCH who achieved complete remission with pharmacological therapy and remains relapse-free.
Area of Science:
- Pediatric Oncology
- Histiocytosis
- Rare Diseases
Background:
- Langerhans cell histocytosis (LCH) is a rare clonal proliferative disorder.
- While predominantly affecting children under 15, LCH can occur at any age.
- Multisystem LCH involves widespread dissemination to various organs and tissues.
Abstract:
Langerhans cell histocytosis is a rare disease. LCH is reported mainly in children aged less than 15 years, however it may appear at any age. In this work, the case of 17-month boy is reported. The boy was admitted to the pediatric ophthalmology department in order to diagnose the swelling and bruising in the lower part of left orbit, which had lasted for one month before. The clinical status, various imaging techniques' results (MRI, TK and PET) and immunohistochemistry led to the final diagnosis of multisystem LCH (spread to masticator muscle and zygomatic bone). After the pharmacological therapy the total remission was achieved. Since four years the child is regularly controlled by oncologists and hematologists with no relapse reported.
