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Related Experiment Video

Updated: Mar 7, 2026

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
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Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development.

K E Boschen1, A Y Klintsova1

  • 1University of Delaware, Newark, DE, United States.

Vitamins and Hormones
|February 21, 2017
PubMed
Summary
This summary is machine-generated.

Alcohol exposure during development harms fetal brain growth, impacting cognition and behavior. Neurotrophic factors may offer neuroprotection against these alcohol-induced developmental effects.

Keywords:
Adult neurogenesisApoptosisBDNFCNSDendritesFASDHippocampusNeuroplasticityNeuroprotectionVEGF

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Toxicology

Background:

  • Fetal alcohol spectrum disorders (FASDs) result from prenatal alcohol exposure.
  • Alcohol exposure significantly impacts fetal brain development, affecting structure, function, and behavior.
  • Neurotrophic factors are crucial for normal brain development and plasticity.

Purpose of the Study:

  • To review the literature on alcohol's effects on neurotrophin production during development.
  • To explore the interactions between prenatal alcohol exposure and neurotrophin signaling pathways.
  • To discuss the potential neuroprotective role of neurotrophins against alcohol-induced damage.

Main Methods:

  • Literature review of existing research on FASDs and neurotrophic factors.
  • Analysis of studies examining alcohol's impact on neurotrophin production and action.
  • Synthesis of findings across various biological and behavioral domains.

Main Results:

  • Prenatal alcohol exposure disrupts neurotrophin production and signaling.
  • Interactions occur in processes like synaptic plasticity, neurogenesis, and apoptosis.
  • Alcohol exposure affects behaviors related to memory, anxiety, and depression.

Conclusions:

  • Neurotrophins play a critical role in mediating the effects of developmental alcohol exposure.
  • Neurotrophins demonstrate potential as neuroprotective agents against prenatal alcohol harm.
  • Further research into neurotrophin-based interventions for FASDs is warranted.