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A Novel Method of Drug Administration to Multiple Zebrafish Danio rerio and the Quantification of Withdrawal
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BDNF During Withdrawal.

H Geoffroy1, F Noble1

  • 1Université Paris Descartes, Inserm U1124, CNRS ERL3649, Neuroplasticité et Thérapies des addictions, Paris, France.

Vitamins and Hormones
|February 21, 2017
PubMed
Summary
This summary is machine-generated.

Brain-derived neurotrophic factor (BDNF) levels change after drug abuse. Studies show BDNF

Keywords:
AddictionBDNFBiomarkerBrainCravingPlasmaWithdrawal

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Research

Background:

  • Drug abuse significantly alters Brain-Derived Neurotrophic Factor (BDNF) levels in the brain and periphery.
  • These alterations are observed in both preclinical animal models and human studies.

Purpose of the Study:

  • To review adaptations in BDNF levels following drug abuse.
  • To examine the role of BDNF in drug-seeking behavior and relapse.
  • To assess BDNF as a potential biomarker for relapse vulnerability.

Main Methods:

  • Review of preclinical studies in juvenile and adult animals.
  • Analysis of protracted withdrawal and incubation effects on central BDNF.
  • Examination of clinical studies investigating BDNF and relapse.

Main Results:

  • Protracted withdrawal is often linked to increased central BDNF levels.
  • BDNF's role in drug-seeking behavior is complex, showing both enhancement and protective effects.
  • Clinical studies suggest BDNF may serve as a biomarker for relapse vulnerability.

Conclusions:

  • BDNF levels are dynamically altered by drug abuse, with significant implications during withdrawal.
  • The dual role of BDNF in drug-seeking behavior warrants further investigation.
  • BDNF shows promise as a clinical biomarker for predicting relapse risk in individuals with substance use disorders.